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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735427
Species: Mus musculus
RGD Object: Gene
Symbol: Cish
Name: cytokine inducible SH2-containing protein
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cishdecreases expressionEXP 6480464CTDMelatonin results in decreased expression of CISH mRNAPMID:21461237
Cishmultiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]PMID:21461237
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