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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69329
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapt
Name: microtubule-associated protein tau
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7364966480464CTDMelatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]

PMID:10617124
multiple interactionsISORGD:7364976480464CTDMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA], Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein]

PMID:15842767, PMID:23963992
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.