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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:16793
Term: mercury(2+)
Definition: A mercury cation that has formula Hg.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases secretionISORGD:107966480464CTDMercury results in decreased secretion of IL4 protein

PMID:15910788
multiple interactionsISORGD:107966480464CTD[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA, CASP1 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA], IFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA], IL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IL4 mRNA]

PMID:28453771
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.