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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616012
Species: Mus musculus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle, aorta
Acc ID: CHEBI:167670
Term: SCH772984
Definition: A member of the class of indazoles that is 1H-indazole substituted by pyridin-4-yl and {[(3R)-1-(2-oxo-2-{4-[4-(pyrimidin-2-yl)phenyl]piperazin-1-yl}ethyl)pyrrolidin-3-yl]carbonyl}amino groups at positions 3 and 5, respectively. It is a potent inhibitor of mitogen-activated protein kinases ERK1 and ERK2 (IC50 = 4 and 1 nM, respectively) that exhibits anti-cancer properties.
Chemical ID: MESH:C587178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2multiple interactionsEXP 6480464CTDSCH772984 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]PMID:31706003
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