Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


RGD ID: 3258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pax6
Name: paired box 6
Acc ID: CHEBI:167657
Term: CHIR-98014
Definition: A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).
Chemical ID: MESH:C473710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pax6decreases expressionISOPAX6 (Homo sapiens)6480464CTDChir 98014 results in decreased expression of PAX6 mRNAPMID:22723015
Go Back to source page   Continue to Ontology report