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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303178
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nanog
Name: Nanog homeobox
Acc ID: CHEBI:167657
Term: CHIR-98014
Definition: A member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively).
Chemical ID: MESH:C473710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nanogdecreases expressionISORGD:13476866480464CTDChir 98014 results in decreased expression of NANOG mRNA

PMID:22723015
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