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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731071
Species: Homo sapiens
RGD Object: Gene
Symbol: AHR
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AHRdecreases expressionEXP 6480464CTDChenodeoxycholic Acid results in decreased expression of AHR mRNAPMID:27174168
AHRincreases secretionISOAhr (Mus musculus)6480464CTDAHR gene mutant form results in increased secretion of Chenodeoxycholic AcidPMID:32679164
AHRmultiple interactionsISOAhr (Mus musculus)6480464CTD[AHR gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased secretion of Chenodeoxycholic AcidPMID:29452137
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