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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69069
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl5increases expressionISOCCL5 (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of CCL5 mRNA; Chenodeoxycholic Acid results in increased expression of CCL5 proteinPMID:12126966
Ccl5increases expressionISOCcl5 (Mus musculus)6480464CTDChenodeoxycholic Acid results in increased expression of CCL5 mRNAPMID:21224055
Ccl5multiple interactionsISOCCL5 (Homo sapiens)6480464CTDBezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]PMID:12126966
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