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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpbar1
Name: G protein-coupled bile acid receptor 1
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpbar1increases expressionISOGPBAR1 (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of GPBAR1 mRNAPMID:25055961
Gpbar1multiple interactionsISOGPBAR1 (Homo sapiens)6480464CTD[Chenodeoxycholic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Chenodeoxycholic Acid binds to and results in increased activity of GPBAR1 proteinPMID:17963371 PMID:18180267
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