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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11481
Species: Mus musculus
RGD Object: Gene
Symbol: Vcam1
Name: vascular cell adhesion molecule 1
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcam1increases expressionEXP 6480464CTDChenodeoxycholic Acid results in increased expression of VCAM1 mRNAPMID:21224055
Vcam1multiple interactionsEXP 6480464CTDChenodeoxycholic Acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of VCAM1 mRNA]PMID:27773935
Vcam1increases expressionISOVCAM1 (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of VCAM1 mRNA; Chenodeoxycholic Acid results in increased expression of VCAM1 proteinPMID:16582018
Vcam1multiple interactionsISOVCAM1 (Homo sapiens)6480464CTDBAY 11-7085 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of VCAM1 mRNA]PMID:16582018
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