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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:16738
Term: 2,4-dichlorophenol
Definition: A dichlorophenol that is phenol carrying chloro substituents at positions 2 and 4.
Chemical ID: MESH:C004762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD2, 4-dichlorophenol results in increased expression of DDIT3 mRNA, 2, 4-dichlorophenol results in increased expression of DDIT3 protein

PMID:25160872, PMID:27853103
multiple interactionsEXP 6480464CTDtauroursodeoxycholic acid inhibits the reaction [2, 4-dichlorophenol results in increased expression of DDIT3 mRNA]

PMID:27853103
increases expressionISORGD:691656480464CTD2, 4-dichlorophenol results in increased expression of DDIT3 mRNA, 2, 4-dichlorophenol results in increased expression of DDIT3 protein

PMID:27853103
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.