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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737487
Species: Homo sapiens
RGD Object: Gene
Symbol: IFNG
Name: interferon gamma
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGdecreases expressionEXP 6480464CTDBenzene results in decreased expression of IFNG mRNAPMID:15929907 PMID:19162166
IFNGmultiple interactionsEXP 6480464CTDBenzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]PMID:8193360
IFNGmultiple interactionsISOIfng (Mus musculus)6480464CTD[Formaldehyde co-treated with Benzene co-treated with Toluene co-treated with Xylenes] results in decreased expression of IFNG; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with Benzene] results in increased abundance of Nitric Oxide]PMID:22863854 PMID:7884313 PMID:8193360
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