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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737039
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN2A
Name: cyclin dependent kinase inhibitor 2A
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN2Aaffects response to substanceEXP 6480464CTDCDKN2A gene polymorphism affects the susceptibility to BenzenePMID:19596022
CDKN2Adecreases expressionEXP 6480464CTDBenzene results in decreased expression of CDKN2A mRNAPMID:20044985
CDKN2Amultiple interactionsEXP 6480464CTD[Benzene results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA; MDM2 gene polymorphism affects the reaction [CDKN2A gene polymorphism affects the susceptibility to Benzene]PMID:19596022 PMID:20044985
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