Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	735440
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	NFKBIA
Name:	NFKB inhibitor alpha

Acc ID:	CHEBI:16716
Term:	benzene
Definition:	A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID:	MESH:D001554

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
NFKBIA	affects expression	EXP		6480464	CTD	Benzene affects the expression of NFKBIA mRNA	PMID:30300410
NFKBIA	increases expression	EXP		6480464	CTD	Benzene results in increased expression of NFKBIA mRNA	PMID:20359517
NFKBIA	decreases expression	ISO	Nfkbia (Mus musculus)	6480464	CTD	Benzene results in decreased expression of NFKBIA protein	PMID:19812361 PMID:19913523
NFKBIA	increases expression	ISO	Nfkbia (Mus musculus)	6480464	CTD	Benzene results in increased expression of NFKBIA mRNA	PMID:15050406
NFKBIA	multiple interactions	ISO	Nfkbia (Mus musculus)	6480464	CTD	CAT protein inhibits the reaction [Benzene results in decreased expression of NFKBIA protein]	PMID:19812361

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