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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1decreases expressionEXP 6480464CTDBenzene results in decreased expression of GSTP1 proteinPMID:8347175
Gstp1affects metabolic processingISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein affects the metabolism of BenzenePMID:15226677
Gstp1affects response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 gene polymorphism affects the susceptibility to BenzenePMID:15591089
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDBenzene results in increased expression of GSTP1 mRNAPMID:18952161
Gstp1increases metabolic processingISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein results in increased metabolism of BenzenePMID:17885617
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