A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID:
MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene; [Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of aniline; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of chlorobenzene; [Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Toluene; [CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone; [CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol; [Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene; Acrylonitrile inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; Benzene promotes the reaction [CYP2E1 protein results in increased metabolism of Methylene Chloride]; CYP2E1 protein affects the reaction [Benzene results in increased metabolism of Toluene]; daphnetin inhibits the reaction [Benzene results in increased expression of CYP2E1 mRNA]; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene]; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of chlorobenzene]; Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Benzene metabolite]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of Phenol]; EPHX1 protein promotes the reaction [CYP2E1 protein results in increased metabolism of Benzene]; Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]; Progesterone promotes the reaction [Benzene results in decreased activity of CYP2E1 protein]
CYP2E1 gene polymorphism affects the susceptibility to Benzene; CYP2E1 gene SNP affects the susceptibility to Benzene; CYP2E1 protein affects the susceptibility to Benzene
[Acetone results in increased activity of CYP2E1 protein] which results in increased oxidation of Benzene; [Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene; [Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene; [Toluene co-treated with Benzene] results in increased activity of CYP2E1 protein; AHR protein affects the reaction [Benzene results in increased expression of CYP2E1 protein]; dihydroxyethyldithiocarbamate inhibits the reaction [[Benzene results in increased activity of CYP2E1 protein] which results in increased metabolism of 2-dichlorobenzene]; PPP2R1A protein affects the reaction [Benzene results in increased expression of CYP2E1 mRNA]; PPP2R1A protein affects the reaction [Benzene results in increased expression of CYP2E1 protein]
[CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of catechol; [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroquinone; [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroxyhydroquinone; [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of muconic acid; [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of Phenol; [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of S-phenyl-N-acetylcysteine
