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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:16716
Term: benzene
Definition: A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.
Chemical ID: MESH:D001554
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDBenzene results in decreased activity of CAT proteinPMID:21511895
Catdecreases response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein results in decreased susceptibility to Benzene metabolitePMID:10193577
Catmultiple interactionsISOCat (Mus musculus)6480464CTDCAT protein inhibits the reaction [Benzene results in decreased expression of NFKBIA protein]; CAT protein inhibits the reaction [Benzene results in increased abundance of Reactive Oxygen Species]PMID:19812361
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