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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736217
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2D6
Name: cytochrome P450 family 2 subfamily D member 6
Acc ID: CHEBI:16714
Term: codeine
Definition: A morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.
Chemical ID: MESH:D003061
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2D6affects metabolic processingEXP 6480464CTDCYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of CodeinePMID:11823760 PMID:15286053 PMID:15625333
CYP2D6affects response to substanceEXP 6480464CTDCYP2D6 protein polymorphism affects the susceptibility to CodeinePMID:9696456
CYP2D6decreases methylationEXP 6480464CTDCYP2D6 protein results in decreased methylation of CodeinePMID:17470523
CYP2D6increases metabolic processingEXP 6480464CTDCYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of CodeinePMID:10911933 PMID:16595712 PMID:17564651 PMID:21241245
CYP2D6multiple interactionsEXP 6480464CTD[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of MorphinePMID:16595712 PMID:21241245
CYP2D6increases metabolic processingISOCyp2d22 (Mus musculus)6480464CTDCYP2D22 protein results in increased metabolism of CodeinePMID:16595712
CYP2D6multiple interactionsISOCyp2d22 (Mus musculus)6480464CTD[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeinePMID:16595712
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