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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:167099
Term: benzo[d]isothiazol-3-one
Definition: An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.
Chemical ID: MESH:C015699
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases activityISORGD:7365596480464CTD1, 2-benzisothiazoline-3-one results in decreased activity of ESR1 protein

PMID:14702633
Esr1multiple interactionsISORGD:7365596480464CTD1, 2-benzisothiazoline-3-one inhibits the reaction [Estradiol results in increased activity of ESR1 protein]

PMID:14702633
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.