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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735389
Species: Homo sapiens
RGD Object: Gene
Symbol: BBC3
Name: BCL2 binding component 3
Acc ID: CHEBI:167004
Term: fostriecin
Definition: A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.
Chemical ID: MESH:C040313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BBC3multiple interactionsEXP 6480464CTDfostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased expression of BBC3 protein]]PMID:24954032
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