GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | JUN | decreases expression | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | Trichloroethylene results in decreased expression of JUN mRNA | PMID:27618143 | JUN | decreases methylation | ISO | Jun (Mus musculus) | 6480464 | CTD | Trichloroethylene results in decreased methylation of JUN promoter | PMID:10402556 PMID:10774822 | JUN | increases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Trichloroethylene results in increased expression of JUN mRNA; Trichloroethylene results in increased expression of JUN protein | PMID:10774822 PMID:25549359 PMID:27618143 | JUN | increases expression | ISO | Jun (Rattus norvegicus) | 6480464 | CTD | Trichloroethylene results in increased expression of JUN mRNA | PMID:33387578 | JUN | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | [Trichloroethylene results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroethylene results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroethylene results in increased expression of JUN protein] | PMID:10402556 PMID:10774822 | |
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