Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734356
Species: Homo sapiens
RGD Object: Gene
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JUNdecreases expressionISOJun (Rattus norvegicus)6480464CTDTrichloroethylene results in decreased expression of JUN mRNAPMID:27618143
JUNdecreases methylationISOJun (Mus musculus)6480464CTDTrichloroethylene results in decreased methylation of JUN promoterPMID:10402556 PMID:10774822
JUNincreases expressionISOJun (Mus musculus)6480464CTDTrichloroethylene results in increased expression of JUN mRNA; Trichloroethylene results in increased expression of JUN proteinPMID:10774822 PMID:25549359 PMID:27618143
JUNincreases expressionISOJun (Rattus norvegicus)6480464CTDTrichloroethylene results in increased expression of JUN mRNAPMID:33387578
JUNmultiple interactionsISOJun (Mus musculus)6480464CTD[Trichloroethylene results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroethylene results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroethylene results in increased expression of JUN protein]PMID:10402556 PMID:10774822
Go Back to source page   Continue to Ontology report