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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70553
Species: Rattus norvegicus
RGD Object: Gene
Symbol: C5ar1
Name: complement C5a receptor 1
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C5ar1increases expressionISOC5ar1 (Mus musculus)6480464CTDTrichloroethylene results in increased expression of C5AR1 proteinPMID:26095957
C5ar1multiple interactionsISOC5ar1 (Mus musculus)6480464CTDN-((4-dimethylaminophenyl)methyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-carboxamide inhibits the reaction [Trichloroethylene promotes the reaction [C5AR1 protein binds to C5 protein]]; Trichloroethylene promotes the reaction [C5AR1 protein binds to C5 protein]PMID:26095957
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