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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox15
Name: arachidonate 15-lipoxygenase
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox15decreases expressionEXP 6480464CTDTrichloroethylene results in decreased expression of ALOX15 mRNAPMID:33387578
Alox15increases methylationEXP 6480464CTDTrichloroethylene results in increased methylation of ALOX15 genePMID:27618143
Alox15increases expressionISOAlox15 (Mus musculus)6480464CTDTrichloroethylene results in increased expression of ALOX15 mRNAPMID:28973375
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