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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10890
Species: Mus musculus
RGD Object: Gene
Symbol: Me1
Name: malic enzyme 1, NADP(+)-dependent, cytosolic
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Me1increases expressionEXP 6480464CTDTrichloroethylene results in increased expression of ME1 mRNAPMID:25549359
Me1multiple interactionsEXP 6480464CTDTrichloroethylene inhibits the reaction [Dietary Fats affects the expression of ME1 mRNA]PMID:29669109
Me1increases expressionISOMe1 (Rattus norvegicus)6480464CTDTrichloroethylene results in increased expression of ME1 mRNAPMID:19448997
Me1increases methylationISOMe1 (Rattus norvegicus)6480464CTDTrichloroethylene results in increased methylation of ME1 genePMID:27618143
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