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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in decreased activity of CYP19A1 proteinPMID:17599374
Cyp19a1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in decreased expression of CYP19A1 mRNAPMID:12035542
Cyp19a1increases activityISOCYP19A1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of CYP19A1 proteinPMID:15070871
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of CYP19A1 mRNAPMID:20924025
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[Dichlorodiphenyl Dichloroethylene co-treated with bisphenol A] results in decreased activity of CYP19A1 protein; [Dichlorodiphenyl Dichloroethylene co-treated with Chlordecone] results in increased activity of CYP19A1 protein; [Dichlorodiphenyl Dichloroethylene co-treated with FSHB protein] results in increased activity of CYP19A1 protein; [Dichlorodiphenyl Dichloroethylene co-treated with nonylphenol] results in increased activity of CYP19A1 protein; [Dichlorodiphenyl Dichloroethylene co-treated with o,p'-DDT] results in decreased activity of CYP19A1 protein; Dichlorodiphenyl Dichloroethylene results in increased expression of and results in increased activity of CYP19A1 proteinPMID:15070871 PMID:16077170 PMID:17599374
Cyp19a1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of CYP19A1 mRNAPMID:25607892
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