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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpx4decreases expressionISOGpx4 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in decreased expression of GPX4 proteinPMID:25410718
Gpx4increases expressionISOGpx4 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of GPX4 mRNAPMID:25410718
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