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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDDichlorodiphenyl Dichloroethylene binds to PGR protein

PMID:14579009
increases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of PGR mRNA, Dichlorodiphenyl Dichloroethylene results in increased expression of PGR protein

PMID:16859517, PMID:20206645
multiple interactionsEXP 6480464CTDDichlorodiphenyl Dichloroethylene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3, 20-dione results in increased activity of PGR protein], Dichlorodiphenyl Dichloroethylene inhibits the reaction [Progesterone binds to PGR protein], Dichlorodiphenyl Dichloroethylene inhibits the reaction [Progesterone results in increased expression of PGR protein], fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of PGR mRNA]

PMID:14579009, PMID:18262749, PMID:20206645, PMID:26022396
multiple interactionsISORGD:33176480464CTD[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA

PMID:25607892
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.