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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344671
Species: Homo sapiens
RGD Object: Gene
Symbol: TFF1
Name: trefoil factor 1
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFF1increases expressionEXP 6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of TFF1 mRNAPMID:20206645
TFF1multiple interactionsEXP 6480464CTD[Dichlorodiphenyl Dichloroethylene co-treated with Dihydrotestosterone co-treated with Estradiol] results in increased expression of TFF1 mRNA; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of TFF1 mRNA]PMID:18275596 PMID:20206645
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