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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2multiple interactionsEXP 6480464CTD[diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3,5,6-trichloro-2-pyridinol co-treated with 3-phenoxybenzoic acid co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ESR2 mRNAPMID:32518293
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene binds to ESR2 proteinPMID:17713618
Esr2increases activityISOEsr2 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of ESR2 proteinPMID:9860891
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene analog results in increased activity of ESR2 proteinPMID:15064155
Esr2multiple interactionsISOEsr2 (Rattus norvegicus)6480464CTD[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 proteinPMID:9860891
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