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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:16583
Term: butane-2,3-dione
Definition: An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.
Chemical ID: MESH:D003931
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDDiacetyl results in increased phosphorylation of EGFR proteinPMID:30851105
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTDN-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Diacetyl results in increased phosphorylation of EGFR protein]PMID:30851105
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