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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:16581
Term: pregnenolone
Definition: A 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20.
Chemical ID: MESH:D011284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases chemical synthesisEXP 6480464CTDCYP11A1 protein results in increased chemical synthesis of Pregnenolone

PMID:16054388, PMID:19900470
multiple interactionsISORGD:693256480464CTD[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of Pregnenolone

PMID:23873838
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.