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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:16509
Term: 1,4-benzoquinone
Definition: The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene.
Chemical ID: MESH:C004532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionEXP 6480464CTDquinone analog results in increased expression of CDKN1A proteinPMID:33961949
Cdkn1amultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [quinone analog results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [quinone analog results in increased expression of CDKN1A protein]PMID:33961949
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDquinone results in increased expression of CDKN1A mRNAPMID:14976336
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