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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTDThioctic Acid inhibits the reaction [amyloid beta-protein (25-35) results in increased expression of RELA protein]; Thioctic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]PMID:29233029 PMID:34133789
Reladecreases phosphorylationISORela (Mus musculus)6480464CTDThioctic Acid results in decreased phosphorylation of RELA proteinPMID:22488045
Relamultiple interactionsISORela (Mus musculus)6480464CTDThioctic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of RELA protein]PMID:22488045
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