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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620672
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apln
Name: apelin
Acc ID: CHEBI:16494
Term: lipoic acid
Definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Chemical ID: MESH:D008063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aplnincreases expressionISOApln (Mus musculus)6480464CTDThioctic Acid results in increased expression of APLN mRNAPMID:21461750
Aplnincreases secretionISOApln (Mus musculus)6480464CTDThioctic Acid results in increased secretion of APLN proteinPMID:21461750
Aplnmultiple interactionsISOApln (Mus musculus)6480464CTDacadesine inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA]; acadesine inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein]PMID:21461750
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