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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61853
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpc1
Name: glypican 1
Acc ID: CHEBI:16480
Term: nitric oxide
Definition: A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom.
Chemical ID: MESH:D009569
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases nitrosationISORGD:621456480464CTDNitric Oxide results in increased nitrosation of GPC1 protein

PMID:16923158
multiple interactionsISORGD:621456480464CTD[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form, Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form]

PMID:15677459
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.