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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737291
Species: Homo sapiens
RGD Object: Gene
Symbol: MGP
Name: matrix Gla protein
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MGPincreases expressionEXP 6480464CTDEstradiol results in increased expression of MGP mRNAPMID:16202921 PMID:16514628 PMID:19619570 PMID:21185374 PMID:28591870 PMID:28711546
MGPmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MGP mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MGP mRNA]PMID:19619570 PMID:21185374
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