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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of CYP17A1 mRNA; Estradiol results in decreased expression of CYP17A1 proteinPMID:11509743 PMID:17158782 PMID:28476547
Cyp17a1increases expressionEXP 6480464CTDEstradiol results in increased expression of CYP17A1 mRNAPMID:18281260 PMID:23684557 PMID:30196065
Cyp17a1multiple interactionsEXP 6480464CTD[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of CYP17A1 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of CYP17A1 mRNA; bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 mRNA]; bisphenol A promotes the reaction [Estradiol results in increased expression of CYP17A1 protein]; ESR1 protein affects the reaction [Estradiol results in decreased expression of CYP17A1 mRNA]PMID:11509743 PMID:17158782 PMID:28476547
Cyp17a1affects expressionISOCyp17a1 (Rattus norvegicus)6480464CTDEstradiol affects the expression of CYP17A1 mRNAPMID:32145629 PMID:36931579
Cyp17a1decreases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of CYP17A1 mRNA; Estradiol results in decreased expression of CYP17A1 proteinPMID:20144698
Cyp17a1multiple interactionsISOCyp17a1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of CYP17A1 mRNA; Fulvestrant inhibits the reaction [Estradiol affects the expression of CYP17A1 mRNA]PMID:26496021 PMID:36931579
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