Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737121
Species: Mus musculus
RGD Object: Gene
Symbol: Ccn5
Name: cellular communication network factor 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn5increases expressionEXP 6480464CTDEstradiol results in increased expression of CCN5 mRNAPMID:19484750
Ccn5affects expressionISOCCN5 (Homo sapiens)6480464CTDEstradiol affects the expression of CCN5 mRNAPMID:14699072
Ccn5increases expressionISOCCN5 (Homo sapiens)6480464CTDEstradiol results in increased expression of CCN5 mRNAPMID:10944450 PMID:17872378 PMID:19167446 PMID:19484750 PMID:19619570 PMID:23384675 PMID:29389661 PMID:31646340 PMID:36828454
Ccn5multiple interactionsISOCCN5 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of CCN5 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CCN5 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of CCN5 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of CCN5 mRNA; ESR1 protein affects the reaction [Estradiol results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA]; ESR2 protein affects the reaction [Estradiol results in increased expression of CCN5 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to CCN5 promoter]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCN5 mRNA]PMID:10944450 PMID:14699072 PMID:17404688 PMID:17872378 PMID:18692832 PMID:19619570 PMID:20660070 PMID:23384675 PMID:29389661 PMID:30165855
Ccn5multiple interactionsISOCcn5 (Rattus norvegicus)6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of WISP2 mRNAPMID:32741896
Go Back to source page   Continue to Ontology report