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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736636
Species: Homo sapiens
RGD Object: Gene
Symbol: GLS
Name: glutaminase
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GLSaffects expressionEXP 6480464CTDEstradiol affects the expression of GLS mRNAPMID:22574217
GLSincreases expressionEXP 6480464CTDEstradiol results in increased expression of GLS mRNA; Estradiol results in increased expression of GLS proteinPMID:27514991 PMID:31614463
GLSmultiple interactionsEXP 6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of GLS protein]; MYC protein promotes the reaction [Estradiol results in increased expression of GLS protein]PMID:27514991
GLSdecreases expressionISOGls (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of GLS mRNAPMID:32145629
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