GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AR | affects activity | EXP | | 6480464 | CTD | Estradiol affects the activity of AR protein | PMID:15084347 | AR | affects binding | EXP | | 6480464 | CTD | Estradiol binds to AR protein | PMID:14751673 | AR | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of AR mRNA; Estradiol results in decreased expression of AR mRNA mutant form; Estradiol results in decreased expression of AR protein | PMID:11867264 PMID:12391264 PMID:15950459 PMID:18275596 PMID:21185374 PMID:27163517 | AR | increases activity | EXP | | 6480464 | CTD | Estradiol results in increased activity of AR protein; Estradiol results in increased activity of AR protein mutant form | PMID:11861974 PMID:11861975 PMID:12391264 PMID:15026081 PMID:15171712 PMID:20821581 PMID:26867867 PMID:9073609 PMID:9846162 | AR | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of AR mRNA; Estradiol results in increased expression of AR protein | PMID:15026081 PMID:15159206 PMID:15849065 PMID:17823853 PMID:21632903 PMID:23982890 | AR | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [Estradiol results in increased activity of AR protein]; 6-methyl-1,3,8-trichlorodibenzofuran inhibits the reaction [Estradiol results in increased activity of AR protein]; [Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR mRNA; [Dihydrotestosterone co-treated with Estradiol] results in increased expression of AR protein; [Estradiol co-treated with TGFB1 protein] results in decreased expression of AR mRNA; [Fulvestrant co-treated with Estradiol] results in decreased expression of AR protein; [Ospemifene co-treated with Estradiol] results in decreased expression of AR protein; [Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of AR protein; [Tamoxifen co-treated with Estradiol] results in decreased expression of AR protein; [Testosterone co-treated with Estradiol co-treated with Corticosterone] promotes the reaction [AR protein binds to TRAF6 protein]; AR protein affects the reaction [Estradiol results in increased expression of KLK3 mRNA]; AR protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein mutant form]; bicalutamide inhibits the reaction [Estradiol results in increased activity of AR protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR mRNA]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR protein]; Dihydrotestosterone inhibits the reaction [Estradiol results in decreased expression of AR protein]; Estradiol binds to and results in decreased activity of AR protein; Estradiol binds to and results in increased activity of AR protein; Estradiol inhibits the reaction [Metribolone results in increased activity of AR protein]; Estradiol inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Estradiol promotes the reaction [ESR1 protein binds to AR protein]; Estradiol results in increased activity of and results in increased localization of AR protein; Fulvestrant inhibits the reaction [Estradiol results in increased activity of AR protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of AR mRNA]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR mRNA]; hydroxyflutamide inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of AR protein]; hydroxyflutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Estradiol results in decreased expression of AR protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AR protein] | PMID:12391264 PMID:12676605 PMID:15026081 PMID:15171712 PMID:15994348 PMID:17131305 PMID:17823853 PMID:18275596 PMID:18324785 PMID:25752796 PMID:27163517 PMID:29162470 PMID:29389661 PMID:29625166 PMID:30165855 | AR | affects binding | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | Estradiol binds to AR protein | PMID:14565775 PMID:31836225 | AR | decreases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of AR mRNA | PMID:11509743 | AR | increases abundance | ISO | Ar (Mus musculus) | 6480464 | CTD | AR gene mutant form results in increased abundance of Estradiol | PMID:25434310 | AR | increases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of AR mRNA | PMID:23144751 | AR | increases expression | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of AR mRNA; Estradiol results in increased expression of AR protein | PMID:16311018 PMID:17589598 PMID:29055809 | AR | multiple interactions | ISO | Ar (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of AR mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of AR mRNA | PMID:11509743 | | ||||||||||||||||||||||
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