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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734437
Species: Homo sapiens
RGD Object: Gene
Symbol: CTSB
Name: cathepsin B
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTSBincreases expressionEXP 6480464CTDEstradiol results in increased expression of CTSB mRNA; Estradiol results in increased expression of CTSB proteinPMID:23219593 PMID:28844962
CTSBmultiple interactionsEXP 6480464CTD3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CTSB protein]; [Estradiol co-treated with TGFB1 protein] results in increased expression of CTSB mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CTSB protein]PMID:28844962 PMID:30165855
CTSBincreases expressionISOCtsb (Mus musculus)6480464CTDEstradiol results in increased expression of CTSB mRNAPMID:11509743 PMID:15289156
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