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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bincreases phosphorylationEXP 6480464CTDEstradiol results in increased phosphorylation of GSK3B proteinPMID:15845746
Gsk3bmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]PMID:15845746
Gsk3baffects expressionISOGSK3B (Homo sapiens)6480464CTDEstradiol affects the expression of GSK3B mRNAPMID:22574217
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDEstradiol results in increased phosphorylation of GSK3B proteinPMID:16076840
Gsk3bmultiple interactionsISOGsk3b (Rattus norvegicus)6480464CTDEstradiol inhibits the reaction [Progesterone results in decreased expression of GSK3B mRNA]PMID:17170212
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]]; Estradiol inhibits the reaction [ESR1 protein binds to GSK3B protein]; wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]PMID:16076840 PMID:26990689
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