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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733062
Species: Mus musculus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baddecreases expressionISOBAD (Homo sapiens)6480464CTDEstradiol results in decreased expression of BAD mRNAPMID:23373633
Badmultiple interactionsISOBad (Rattus norvegicus)6480464CTD[Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAD mRNA; Estradiol inhibits the reaction [Dimethylnitrosamine results in increased expression of BAD protein]PMID:14659978 PMID:20732338
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