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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732833
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF4E
Name: eukaryotic translation initiation factor 4E
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF4Eaffects expressionEXP 6480464CTDEstradiol affects the expression of EIF4E mRNAPMID:21826169
EIF4Edecreases phosphorylationEXP 6480464CTDEstradiol results in decreased phosphorylation of EIF4E proteinPMID:16033851
EIF4Eincreases expressionEXP 6480464CTDEstradiol results in increased expression of EIF4E mRNAPMID:31614463
EIF4Emultiple interactionsEXP 6480464CTDeverolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]PMID:16033851
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