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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of GSTP1 mRNAPMID:17982697
GSTP1multiple interactionsEXP 6480464CTDEstradiol analog inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; Estradiol inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]PMID:23769903
GSTP1decreases expressionISOGstp1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of GSTP1 mRNAPMID:31119341 PMID:32145629
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