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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732079
Species: Mus musculus
RGD Object: Gene
Symbol: Plat
Name: plasminogen activator, tissue
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plataffects expressionISOPLAT (Homo sapiens)6480464CTDEstradiol affects the expression of PLAT mRNAPMID:22574217
Platincreases expressionISOPlat (Rattus norvegicus)6480464CTDEstradiol results in increased expression of PLAT mRNAPMID:20838740
Platincreases expressionISOPLAT (Homo sapiens)6480464CTDEstradiol results in increased expression of PLAT mRNAPMID:15219790 PMID:19619570 PMID:23019147 PMID:31614463 PMID:36828454
Platincreases secretionISOPLAT (Homo sapiens)6480464CTDEstradiol results in increased secretion of PLAT proteinPMID:3119194
Platmultiple interactionsISOPlat (Rattus norvegicus)6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLAT mRNAPMID:32741896
Platmultiple interactionsISOPLAT (Homo sapiens)6480464CTD2,3,7,8-tetrachlorodibenzofuran inhibits the reaction [Estradiol results in increased secretion of PLAT protein]; [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA; [Estradiol co-treated with Norethindrone Acetate] results in decreased expression of PLAT protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of PLAT mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of PLAT protein]PMID:17393018 PMID:19619570 PMID:20823114 PMID:30165855 PMID:3119194
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