GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Plat | affects expression | ISO | PLAT (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of PLAT mRNA | PMID:22574217 | Plat | increases expression | ISO | Plat (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of PLAT mRNA | PMID:20838740 | Plat | increases expression | ISO | PLAT (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of PLAT mRNA | PMID:15219790 PMID:19619570 PMID:23019147 PMID:31614463 PMID:36828454 | Plat | increases secretion | ISO | PLAT (Homo sapiens) | 6480464 | CTD | Estradiol results in increased secretion of PLAT protein | PMID:3119194 | Plat | multiple interactions | ISO | Plat (Rattus norvegicus) | 6480464 | CTD | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of PLAT mRNA | PMID:32741896 | Plat | multiple interactions | ISO | PLAT (Homo sapiens) | 6480464 | CTD | 2,3,7,8-tetrachlorodibenzofuran inhibits the reaction [Estradiol results in increased secretion of PLAT protein]; [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA; [Estradiol co-treated with Norethindrone Acetate] results in decreased expression of PLAT protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of PLAT mRNA; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of PLAT protein] | PMID:17393018 PMID:19619570 PMID:20823114 PMID:30165855 PMID:3119194 | |
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