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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731684
Species: Mus musculus
RGD Object: Gene
Symbol: Cdc25b
Name: cell division cycle 25B
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdc25baffects expressionISOCdc25b (Rattus norvegicus)6480464CTDEstradiol affects the expression of CDC25B mRNAPMID:32145629
Cdc25bincreases expressionISOCDC25B (Homo sapiens)6480464CTDEstradiol results in increased expression of CDC25B proteinPMID:20208560
Cdc25bmultiple interactionsISOCDC25B (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of CDC25B mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CDC25B protein]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of CDC25B protein]PMID:20208560 PMID:30165855
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