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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731551
Species: Homo sapiens
RGD Object: Gene
Symbol: GCLM
Name: glutamate-cysteine ligase modifier subunit
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GCLMincreases expressionEXP 6480464CTDEstradiol results in increased expression of GCLM mRNAPMID:20106945 PMID:31614463
GCLMaffects expressionISOGclm (Rattus norvegicus)6480464CTDEstradiol affects the expression of GCLM mRNAPMID:22389237
GCLMincreases expressionISOGclm (Rattus norvegicus)6480464CTDEstradiol results in increased expression of GCLM mRNAPMID:32145629
GCLMmultiple interactionsISOGclm (Rattus norvegicus)6480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]PMID:22389237
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