GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | increases expression | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of NFKB1 mRNA | PMID:19401270 PMID:31614463 PMID:34719554 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; dienogest inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Estradiol inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; Estradiol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Estradiol promotes the reaction [TNF protein results in increased activity of NFKB1 protein]; Mifepristone inhibits the reaction [Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]]; Progesterone inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] | PMID:10614622 PMID:12574206 PMID:15866594 | | ||||||||||||||||||||||
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