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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730871
Species: Homo sapiens
RGD Object: Gene
Symbol: PRLR
Name: prolactin receptor
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRLRdecreases expressionEXP 6480464CTDEstradiol results in decreased expression of PRLR mRNAPMID:23373633
PRLRincreases expressionEXP 6480464CTDEstradiol results in increased expression of PRLR mRNAPMID:16202921 PMID:17121429 PMID:21795739 PMID:31614463 PMID:33728745
PRLRmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of PRLR mRNAPMID:20660070
PRLRincreases expressionISOPrlr (Mus musculus)6480464CTDEstradiol results in increased expression of PRLR mRNAPMID:19484750
PRLRincreases expressionISOPrlr (Rattus norvegicus)6480464CTDEstradiol results in increased expression of PRLR mRNA; Estradiol results in increased expression of PRLR mRNA alternative formPMID:26372666 PMID:32145629 PMID:8046303
PRLRmultiple interactionsISOPrlr (Rattus norvegicus)6480464CTD[Progesterone co-treated with Estradiol] results in decreased expression of PRLR mRNAPMID:16107292
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